反应详情

While 56.9 g of 1-(4-methoxy-phenyl)-3-methyl-butan-1-one (3) prepared in Example 1 were added to 200 ml of ethylacetate and stirred, 18.2 ml of bromine were added at room temperature and stirring was continued at the same temperature for 1 hr. After the reaction was completed, the resultant reaction mixture was washed with brine and water, in that order, after which the ethylacetate layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure, thus obtaining 77.0 g (yield: 96.0%) of a title compound as light yellow liquid.

1. stirringstirring
2. customthe resultant reaction mixture
3. washwas washed with brine and water, in that order
4. dry with materialafter which the ethylacetate layer was dried over anhydrous magnesium sulfate
5. concentrationconcentrated under reduced pressure