Cyclohexanecarbonyl chloride → N-{4-[(4-butylphenyl)ethynyl)benzyl}-N-(2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-6-yl)cyclohexanecarboxamide
Reaction equation
Cl.[CH2:2]([C:6]1[CH:11]=[CH:10][C:9]([C:12]#[C:13][C:14]2[CH:34]=[CH:33][C:17]([CH2:18][NH:19][C:20]3[CH:32]=[CH:31][C:23]4[O:24][C:25]([CH3:30])([CH3:29])[O:26][C:27](=[O:28])[C:22]=4[CH:21]=3)=[CH:16][CH:15]=2)=[CH:8][CH:7]=1)[CH2:3][CH2:4][CH3:5].[CH:35]1([C:41](Cl)=[O:42])[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]1>>[CH2:2]([C:6]1[CH:7]=[CH:8][C:9]([C:12]#[C:13][C:14]2[CH:34]=[CH:33][C:17]([CH2:18][N:19]([C:20]3[CH:32]=[CH:31][C:23]4[O:24][C:25]([CH3:30])([CH3:29])[O:26][C:27](=[O:28])[C:22]=4[CH:21]=3)[C:41]([CH:35]3[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]3)=[O:42])=[CH:16][CH:15]=2)=[CH:10][CH:11]=1)[CH2:3][CH2:4][CH3:5]Participants
3
Procedure
The titled compound was prepared following the procedure J using 6-({4-[(4-butylphenyl)ethynyl]benzyl}amino)-2,2-dimethyl-4H-1,3-benzodioxin-4-one hydrochloride and cyclohexanecarbonyl chloride as a colorless oil (86%). 1H NMR (CDCl3, 300 MHz) δ 7.70 (d, J=2.3 Hz, 1H), 7.43 (m, 4H), 7.15 (m, 4H), 7.04 (dd, J=8.7, 2.3 Hz, 1H), 6.91 (d, J=8.7 Hz, 1H), 4.86 (s, 2H), 2.63 (t, J=7.7 Hz, 2H), 2.10 (m, 1H), 1.76 (s, 6H), 1.75-1.56 (m, 10H), 1.42-0.97 (m, 4H), 0.94 (t, J=7.4 Hz, 3H). M+ (ESI): 550.8. HPLC, Rt: 6.45 min (Purity: 100%).
Sources & evidence
- ORD record
- ord-35650de4ef8f4118945112edfdba3491
- Source dataset
- uspto-grants-2009_09
- Patent number
- US07589232B2
Reaction notes
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