Hexanoyl chloride → N-{4-[(4-butylphenyl)ethynyl]benzyl}-N-(2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-6-yl)hexanamide
Reaction equation
Cl.[CH2:2]([C:6]1[CH:11]=[CH:10][C:9]([C:12]#[C:13][C:14]2[CH:34]=[CH:33][C:17]([CH2:18][NH:19][C:20]3[CH:32]=[CH:31][C:23]4[O:24][C:25]([CH3:30])([CH3:29])[O:26][C:27](=[O:28])[C:22]=4[CH:21]=3)=[CH:16][CH:15]=2)=[CH:8][CH:7]=1)[CH2:3][CH2:4][CH3:5].[C:35](Cl)(=[O:41])[CH2:36][CH2:37][CH2:38][CH2:39][CH3:40]>>[CH2:2]([C:6]1[CH:7]=[CH:8][C:9]([C:12]#[C:13][C:14]2[CH:34]=[CH:33][C:17]([CH2:18][N:19]([C:20]3[CH:32]=[CH:31][C:23]4[O:24][C:25]([CH3:30])([CH3:29])[O:26][C:27](=[O:28])[C:22]=4[CH:21]=3)[C:35](=[O:41])[CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])=[CH:16][CH:15]=2)=[CH:10][CH:11]=1)[CH2:3][CH2:4][CH3:5]Participants
3
Procedure
The titled compound was prepared following the procedure B using 6-({4-[(4-butylphenyl)ethynyl]benzyl}amino)-2,2-dimethyl-4H-1,3-benzodioxin-4-one hydrochloride and hexanoyl chloride as a colorless oil (88%). 1H NMR (CDCl3, 300 MHz) δ 7.70 (d, J=2.3 Hz, 1H), 7.44 (m, 4H), 7.16 (m, 4H), 7.05 (dd, J=8.6, 2.3 Hz, 1H), 6.91 (d, J=8.6 Hz, 1H) 4.88 (s, 2H), 2.63 (t, J=7.7 Hz, 2H), 2.06 (t, J=7.5 Hz. 2H), 1.75 (s, 6H), 1.61 (m, 4H), 1.36 (m, 2H), 1.23 (m, 4H), 0.94 (t, J=7.3 Hz, 3H), 0.85 (t, J=6.8 Hz, 3H). M+ (ESI): 538.4 HPLC, Rt: 5.95 min (Purity: 98.2%).
Sources & evidence
- ORD record
- ord-95a88f6fe44e4a39afb767bd9ea21136
- Source dataset
- uspto-grants-2009_09
- Patent number
- US07589232B2
Reaction notes
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