反应详情

The titled compound was prepared following the procedure J using 6-({4-[(4-butylphenyl)ethynyl]benzyl}amino)-2,2-dimethyl-4H-1,3-benzodioxin-4-one hydrochloride and 2,3-dihydro-1-benzofuran-5-carbonyl chloride as a colorless oil (92%). 1H NMR (CDCl3, 300 MHz) δ 7.66 (d, J=2.7 Hz, 1H), 7.44 (m, 4H), 7.34 (brs, 1H), 7.26 (d, J=8.3 Hz, 2H), 7.16 (d, J=8.0 Hz, 2H), 7.02 (m, 1H), 6.97 (dd, J=8.6, 2.7 Hz, 1H), 6.74 (d, J=8.6 Hz, 1H), 6.52 (d, J=8.3 Hz, 1H), 5.12 (s, 2H), 4.55 (t, J=8.9 Hz, 2H), 3.12 (t, J=8.9 Hz, 2H), 2.62 (t, J=7.8 Hz, 2H), 1.69 (s, 6H), 1.61 (m, 2H), 1.36 (m, 2H), 0.93 (t, J=7.4 Hz, 3H). M+ (ESI): 586.4. HPLC, Rt: 6.05 min (Purity: 100%).