反应详情

The titled compound was prepared following the procedure A using 6-[(4-butylphenyl)ethynyl]nicotinaldehyde and 6-amino-2,2-dimethyl-benzo[1,3]dioxin-4-one as a yellow powder (22%). 1H NMR (CDCl3, 300 MHz) δ 8.61 (s, 1H), 7.66 (m, 1H), 7.48 (m, 3H), 7.16 (m, 3H), 6.87-6.76 (m, 2H), 4.36 (s, 2H), 2.61 (t, J=7.7 Hz, 2H), 1.69 (s, 6H), 1.66-1.54 (m, 2H), 1.41-1.28 (m, 2H), 0.92 (t, J=7.2 Hz, 3H). M− (ESI): 439.1; M+ (ESI): 441.4. HPLC, Rt: 4.55 min (Purity: 85.3%).