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HRID733697

反应详情

EQUATION

反应方程式

HRID 733697 的结构方程式

REACTANTS

反应物

2
结构：COc1cccc(N)c1
HCID10824

3-Methoxyaniline

C7H9NO

结构：Cc1cn(C(=O)OC(C)(C)C)c2c(Cl)ncc(C(=O)N3CCCCC3)c12
HCID57840991

1,1-Dimethylethyl 7-chloro-3-methyl-4-(1-piperidinylcarbonyl)-1H-pyrrolo[2,3-c]pyridine-1-carboxylate

C19H24ClN3O3

PRODUCTS

生成物

1
结构：COc1cccc(Nc2ncc(C(=O)N3CCCCC3)c3c(C)c[nH]c23)c1
HCID57840939

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOCC
溶剂HCID3283

Diethyl Ether

C4H10O

PROCEDURE

实验过程

Prepared in a similar manner to Example 4(d) from 7-chloro-3-methyl-4-(1-piperidin-1-yl-methanoyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester (90 mg) and using 3-methoxyaniline (54 ul) instead of 3-bromoaniline and heating for 15 rather than 30 minutes. Isolated by MDAP rather than trituration with diethyl ether to give 1-[7-(3-methoxy-phenylamino)-3-methyl-1H-pyrrolo[2,3-c]pyridin-4-yl]-1-piperidin-1-yl-methanone (65 mg).

WORKUP

后处理

  1. temperatureheating for 15 rather than 30 minutes