反应详情

To a solution of phenylmethyl 2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-hydroxy-8-azaspiro[4.5]decane-8-carboxylate (˜3.1 g, 7.65 mmol) in EtOH (38 mL) was added Pd(OH)2 (1.5 g, 50 wt %). The solution was hydrogenated using a Parr Shaker at 50 psi. After 2 h, the solution was filtered through Celite®, concentrated and purified by column chromatography (silica, 15% MeOH in DCM (1% NH4OH)) yielding the title compound (618 mg, 31%-2 steps) as a yellow oil: LCMS (ES) m/e 272 (M+H)+.

1. filtrationthe solution was filtered through Celite®
2. concentrationconcentrated
3. custompurified by column chromatography (silica, 15% MeOH in DCM (1% NH4OH))