HRID735945

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2775133

1-Ethynyl-4-propylbenzene

C11H12

结构：CCOC(=O)C(=O)N(Cc1ccc(C(F)(F)F)cc1)Cc1ccc2occ(Br)c2c1

HCID67188647

未命名化合物

PRODUCTS

生成物

结构：CCCc1ccc(C#Cc2coc3ccc(CN(Cc4ccc(C(F)(F)F)cc4)C(=O)C(=O)OCC)cc23)cc1

HCID67186980

未命名化合物

收率 5%

PROCEDURE

实验过程

The same procedure as employed in the preparation of Example 226 (step c) but using ethyl{[(3-bromo-1-benzofuran-5-yl)methyl][4-(trifluoromethyl)benzyl]amino}(oxo)acetate and 1-ethynyl-4-propylbenzene under microwave conditions (300 W, 120° C., 10 min) gave the title compound as a yellow oil (5%). M−(LC/MS(ESI)): 545.8; M+(LC/MS(ESI)): 548.2 HPLC (Condition A), Rt: 5.85 min (HPLC purity: 92.4%).

WORKUP

后处理

customThe same procedure as employed in the preparation of Example 226 (step c)
customunder microwave conditions (300 W, 120° C., 10 min)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-64c1fa1ca3dd41dead922fbe6dda88ec
来源数据集: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07592477B2
来源说明: uspto-grants-2009_09

反应 SMILES

[CH2:1]([O:3][C:4](=[O:30])[C:5]([N:7]([CH2:19][C:20]1[CH:21]=[CH:22][C:23]2[O:27][CH:26]=[C:25](Br)[C:24]=2[CH:29]=1)[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=1)=[O:6])[CH3:2].[C:31]([C:33]1[CH:38]=[CH:37][C:36]([CH2:39][CH2:40][CH3:41])=[CH:35][CH:34]=1)#[CH:32]>>[CH2:1]([O:3][C:4](=[O:30])[C:5](=[O:6])[N:7]([CH2:19][C:20]1[CH:21]=[CH:22][C:23]2[O:27][CH:26]=[C:25]([C:32]#[C:31][C:33]3[CH:38]=[CH:37][C:36]([CH2:39][CH2:40][CH3:41])=[CH:35][CH:34]=3)[C:24]=2[CH:29]=1)[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=1)[CH3:2]