反应详情

The title compound was prepared in an analogous fashion to that described in Example 8 using (R)-5-bromo-N-(4-(2-chloro-1,1,2,2-tetrafluoroethyl)phenyl)-6-(3-hydroxypyrrolidin-1-yl)nicotinamide (Stage 31.1) and 1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole to afford a white powder. HPLC (Condition 4) tR=4.89 min, UPLC-MS (Condition 3) tR=0.98 min, m/z=484.1 [M+H]+; 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.65-1.89 (m, 2H) 2.83-2.98 (m, 1H) 3.18-3.33 (m, 2H) 3.36-3.49 (m, 1H) 4.13-4.24 (m, 1H) 4.77-4.93 (m, 1H) 6.31-6.43 (m, 1H) 7.62 (d, J=8.59 Hz, 2H) 7.77-7.84 (m, 1H) 7.91-8.09 (m, 3H) 8.64-8.81 (m, 1H) 10.31 (s, 1H) 12.83-12.96 (m, 1H).

1. customto afford a white powder