反应详情

A mixture of 3-cyano-1-(furan-3-yl)-6-iodonaphthalene (2.5 g, 7.25 mmol), 2-(trimethylsilyl)ethanethiol (974 mg, 7.25 mmol), potassium tert-butoxide (1.624 g, 14.5 mmol) and (Ph3P)4Pd (200 mg, 0.17 mmol) in EtOH (250 mL) was refluxed for 6.5 h. After evaporation of the EtOH, the residue was partitioned between Et2O and H2O. The crude product from the organic phase was chromatographed on silica gel, eluting with a 1:9 mixture of EtOAc and hexane to afford the title product (1.8 g) as an amber oil.

1. temperaturewas refluxed for 6.5 h
2. customAfter evaporation of the EtOH
3. customthe residue was partitioned between Et2O and H2O
4. customThe crude product from the organic phase was chromatographed on silica gel
5. washeluting with a 1:9 mixture of EtOAc and hexane