反应详情

Following a procedure similar to that described in Example 1(b), a solution of 260 mg of 2-{2-[4-(2-methoxyphenyl)butyl]phenoxymethyl}oxirane [prepared as described in step (a) above] in 10 ml of tetrahydrofuran was treated with 2 ml of 50% by volume aqueous dimethylamine and then worked up. The resulting crude product was purified by column chromatography through silica gel, using a 10:1 by volume mixture of methylene chloride and methanol as the eluent, to give 250 mg (yield 84%) of the title compound as a colorless oil.

1. customThe resulting crude product was purified by column chromatography through silica gel
2. additionby volume mixture of methylene chloride and methanol as the eluent