Dimethylamine → 1-{2-[4-(2-Chlorophenyl)butyl]phenoxy}-3-dimethylamino-2-propanol

HRID 743220Notes

Reaction equation

HRID 743220 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][CH2:10][CH2:11][C:12]1[CH:22]=[CH:21][CH:20]=[CH:19][C:13]=1[O:14][CH2:15][CH:16]1[CH2:18][O:17]1.[CH3:23][NH:24][CH3:25]>O1CCCC1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][CH2:10][CH2:11][C:12]1[CH:22]=[CH:21][CH:20]=[CH:19][C:13]=1[O:14][CH2:15][CH:16]([OH:17])[CH2:18][N:24]([CH3:25])[CH3:23]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 194239262-{2-[4-(2-Chlorophenyl)butyl]phenoxymethyl}oxirane

Product 1

HCID 194239181-{2-[4-(2-Chlorophenyl)butyl]phenoxy}-3-dimethylamino-2-propanolYield 80%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following a procedure similar to that described in Example 1(b), 860 mg of 2-{2-[4-(2-chlorophenyl)butyl]phenoxymethyl}oxirane [prepared as described in step (a) above] dissolved in 20 ml of tetrahydrofuran were treated with 4 ml of 50% by volume aqueous dimethylamine. The crude product thus obtained was purified as described in Example 1(b), to give 790 mg (yield 80%) of the title compound as a colorless oil.

Workup

  1. customThe crude product thus obtained
  2. customwas purified

Sources & evidence

ORD record
ord-493f0a573e49440c9f9db719435b652c
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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