反应详情

Following a procedure similar to that described in Example 1(b), 840 mg of 2-{2-[4-(3-chlorophenyl)butyl]phenoxy methyl]oxirane [prepared as described in step (a) above] dissolved in 20 ml of tetrahydrofuran were treated with 4 ml of 50% by volume aqueous dimethylamine. The crude product was purified by column chromatography through silica gel, using a 10:1 by volume mixture of methylene chloride and methanol as the eluent, to give 789 mg (yield 82%) of the title compound as a colorless oil.

1. customThe crude product was purified by column chromatography through silica gel
2. additionby volume mixture of methylene chloride and methanol as the eluent