反应详情

Following a procedure similar to that described in Example 38, 880 mg of 1-t-butoxycarbonyl-3-{2-[2-(3-methoxyphenyl)ethyl]phenoxy}piperidine [prepared as described in Example 51(a)] were reacted with 162 mg of lithium aluminum hydride. The mixture was then worked up as described in Example 38, and the crude product thus obtained was purified by column chromatography through silica gel, using a 10:1 by volume mixture of methylene chloride and methanol as the eluent, to give 360 mg (yield 51%) of the title compound as a colorless oil.

1. customthe crude product thus obtained
2. customwas purified by column chromatography through silica gel
3. additionby volume mixture of methylene chloride and methanol as the eluent