反应详情

Following a procedure similar to that described in Example 65(b), 550 mg of (4R)-4-benzyloxy-1-t-butoxycarbonyl-2-{2-[2-(3-methylphenyl)ethyl]phenoxymethyl}pyrrolidine [prepared as described in step (a) above] were dissolved in 20 ml of ethanol and hydrogenated in an atmosphere of hydrogen at atmospheric pressure and in the presence of 120 mg of 5% w/w palladium-on-charcoal as a catalyst. The mixture was then worked up as described in Example 65(b), and the crude product thus obtained was purified by column chromatography through silica gel, using a 1:1 by volume mixture of hexane and ethyl acetate as the eluent, to give 370 mg (yield 82%) of the title compound as a colorless oil.

1. customthe crude product thus obtained
2. customwas purified by column chromatography through silica gel
3. additionby volume mixture of hexane and ethyl acetate as the eluent