反应详情

Following a procedure similar to that described in the latter part of Preparation 3, the whole of the benzyl 2-[4-(2-methoxyphenyl)-1-butenyl]phenyl ether prepared as described above was dissolved in 50 ml of ethanol and hydrogenated at 50° C. in an atmosphere of hydrogen at atmospheric pressure and in the presence of 100 mg of 5% w/w palladium-on-charcoal for 6 hours. The crude product thus obtained was purified by column chromatography through silica gel, using 10:1 by volume mixture of hexane and ethyl acetate as the eluent, to give 0.44 g (yield 60%) of the title compound as a colorless oil.

1. customthat described in the latter part of Preparation 3
2. customThe crude product thus obtained
3. customwas purified by column chromatography through silica gel
4. additionby volume mixture of hexane and ethyl acetate as the eluent