3-(2-Amino-2-methylpropoxy)-6-chloropyridazine → 1-[2-(2-Methoxyethyl)phenoxy]-3-[1,1-dimethyl-2-(3-chloro-6-pyridazinyloxy)ethylamino]-2-propanol

HRID 745498노트

반응식

HRID 745498 반응식
[NH2:1][C:2]([CH3:13])([CH3:12])[CH2:3][O:4][C:5]1[N:6]=[N:7][C:8]([Cl:11])=[CH:9][CH:10]=1.[CH3:14][O:15][CH2:16][CH2:17][C:18]1[CH:28]=[CH:27][CH:26]=[CH:25][C:19]=1[O:20][CH2:21][CH:22]1[O:24][CH2:23]1>C(O)C>[CH3:14][O:15][CH2:16][CH2:17][C:18]1[CH:28]=[CH:27][CH:26]=[CH:25][C:19]=1[O:20][CH2:21][CH:22]([OH:24])[CH2:23][NH:1][C:2]([CH3:13])([CH3:12])[CH2:3][O:4][C:5]1[N:6]=[N:7][C:8]([Cl:11])=[CH:9][CH:10]=1

참가 물질

4

반응물 2

HCID 103304683-(2-Amino-2-methylpropoxy)-6-chloropyridazineHCID 233133692-[[2-(2-Methoxyethyl)phenoxy]methyl]oxirane

생성물 1

HCID 103414811-[2-(2-Methoxyethyl)phenoxy]-3-[1,1-dimethyl-2-(3-chloro-6-pyridazinyloxy)ethylamino]-2-propanol수율 38.7%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 4.83 g of 3-(2-amino-2-methylpropoxy)-6-chloropyridazine obtained in Example 1(a), 5.0 g of 1-[2-(2-methoxyethyl)phenoxy]-2,3-epoxypropane and 200 ml of ethanol was refluxed for 4 hours, and the solvent was evaporated under reduced pressure. A solution of the residue in benzene was extracted with 1N hydrochloric acid. The aqueous layer was extracted with chloroform, washed successively with 5% sodium carbonate and water, and the organic layer was dried over magnesium sulfate. The solvent was evaporated to give 3.8 g of 1-[2-(2-methoxyethyl)phenoxy]-3-[1,1-dimethyl-2-(3-chloro-6-pyridazinyloxy)ethylamino]-2-propanol.

후처리

  1. temperaturewas refluxed for 4 hours
  2. customthe solvent was evaporated under reduced pressure
  3. extractionA solution of the residue in benzene was extracted with 1N hydrochloric acid
  4. extractionThe aqueous layer was extracted with chloroform
  5. washwashed successively with 5% sodium carbonate and water
  6. dry with materialthe organic layer was dried over magnesium sulfate
  7. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-f51bd362311644f4b0f181d4901b8554
출처 데이터셋
uspto-grants-1986_07
특허 번호
US04599333

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