反应详情

A mixture of 4.83 g of 3-(2-amino-2-methylpropoxy)-6-chloropyridazine obtained in Example 1(a), 5.0 g of 1-[2-(2-methoxyethyl)phenoxy]-2,3-epoxypropane and 200 ml of ethanol was refluxed for 4 hours, and the solvent was evaporated under reduced pressure. A solution of the residue in benzene was extracted with 1N hydrochloric acid. The aqueous layer was extracted with chloroform, washed successively with 5% sodium carbonate and water, and the organic layer was dried over magnesium sulfate. The solvent was evaporated to give 3.8 g of 1-[2-(2-methoxyethyl)phenoxy]-3-[1,1-dimethyl-2-(3-chloro-6-pyridazinyloxy)ethylamino]-2-propanol.

1. temperaturewas refluxed for 4 hours
2. customthe solvent was evaporated under reduced pressure
3. extractionA solution of the residue in benzene was extracted with 1N hydrochloric acid
4. extractionThe aqueous layer was extracted with chloroform
5. washwashed successively with 5% sodium carbonate and water
6. dry with materialthe organic layer was dried over magnesium sulfate
7. customThe solvent was evaporated