反应详情

In methanol (10 ml) was dissolved 2-[1-[(4-chlorophenyl)sulfonyl]-3-(2-vinyloxyethoxy)propyl]-1,4-difluorobenzene (123 mg, 0.295 mmol). P-toluenesulfonic acid monohydrate (2.0 mg, 0.011 mmol) was added and the mixture was stirred at room temperature for 4 hours. After concentration under reduced pressure, the residue was purified by silica gel chromatography (methylene chloride:methanol=50:1) to yield a white solid. The resulting white solid was washed with hexane, whereby the title compound (80 mg, 70%) was obtained as a white powder.

1. concentrationAfter concentration under reduced pressure
2. customthe residue was purified by silica gel chromatography (methylene chloride:methanol=50:1)
3. customto yield a white solid
4. washThe resulting white solid was washed with hexane, whereby the title compound (80 mg, 70%)
5. customwas obtained as a white powder