反应详情

The 6-(t-butyldimethylsilyloxy)-1-[(4-chlorophenyl)sulfonyl]-1-(2,5-difluorophenyl)-2-hexanol (Isomer 234-A) (42.0 mg, 0.0809 mmol) obtained in Example 234 was dissolved in tetrahydrofuran (2 ml), followed by the addition of hydrogen fluoride-pyridine (0.2 ml). The resulting mixture was stirred at room temperature for 6 hours. The solution was diluted with ethyl acetate, washed with water and brine, dried over magnesium sulfate. The solid thus obtained was recrystallized from ethyl acetate-hexane, whereby the title compound (16.7 mg, 0.0412 mmol, 51%) was obtained as a white powder.

1. washwashed with water and brine
2. dry with materialdried over magnesium sulfate
3. customThe solid thus obtained