反应详情

The 2-[4-(t-butyldimethylsilyloxy)-1-[(4-chlorophenyl)sulfonyl]-2-methylbutyl]-1,4-difluorobenzene (Compound A (Isomer B)) (102 mg, 0.209 mmol) obtained in Example 237 was dissolved in tetrahydrofuran (3 ml), followed by the addition of hydrogen fluoride-pyridine (0.5 ml). The resulting mixture was stirred at room temperature for 15 hours. The reaction mixture was diluted with ethyl acetate, washed with water and brine, and then dried over magnesium sulfate. The solid thus obtained was recrystallized from ethyl acetate-hexane, whereby the title compound (36.1 mg, 0.0963 mmol, 46%) was obtained as colorless columnar crystals.

1. washwashed with water and brine
2. dry with materialdried over magnesium sulfate
3. customThe solid thus obtained