反应详情

To a solution of (1R,2S,3S)-3-((2-(5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)cyclohexane-1,2-diol, 31c, (0.11 g, 0.21 mmol) in THF was added TBAF (0.23 g, 0.84 mmol). The reaction was aged at room temperature 1 hour, quenched with 1N HCl (1 ml), and purified via reverse phase chromatography (5-70% MeCN/H2O with 0.1% TFA). The product was desalted on an SPE bicarbonate cartridge, concentrated to dryness, and then triturated from MeOH to provide 18 mg of compound 632.

1. customquenched with 1N HCl (1 ml)
2. custompurified via reverse phase chromatography (5-70% MeCN/H2O with 0.1% TFA)
3. concentrationconcentrated to dryness
4. customtriturated from MeOH