反应详情

830 mg (2.44 mmole) of the aniline compound obtained in step 1 was dissolved in 10 mL of pyridine, 0.340 mL (2.93 mmoles) of benzoylchloride was added, and the mixture was stirred overnight at room temperature. When the reaction had ended, the solvent was removed under reduced pressure. Ethyl acetate and 1N HCl aqueous solution were added to the residue. The mixture was extracted with ethyl acetate. The obtained organic layer was washed with saturated brine and dried with anhydrous sodium sulfate. The solvent was removed under reduced pressure, yielding 1.11 g of N-benzoylaniline compound.

1. customthe solvent was removed under reduced pressure
2. additionEthyl acetate and 1N HCl aqueous solution were added to the residue
3. extractionThe mixture was extracted with ethyl acetate
4. washThe obtained organic layer was washed with saturated brine
5. dry with materialdried with anhydrous sodium sulfate
6. customThe solvent was removed under reduced pressure