Acetic Anhydride → HCID 69157093, compound

HRID 750349Notes

Reaction equation

HRID 750349 reaction equation
[C:1](OC(=O)C)(=[O:3])[CH3:2].[Br:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[C:15](=[O:19])[N:14]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([S:27]([NH2:30])(=[O:29])=[O:28])=[CH:23][CH:22]=1)[C:13]([C:31](=[O:34])[CH2:32][CH3:33])=[C:12]2[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1>>[Br:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[C:15](=[O:19])[N:14]([CH2:20][C:21]1[CH:22]=[CH:23][C:24]([S:27]([NH:30][C:1](=[O:3])[CH3:2])(=[O:28])=[O:29])=[CH:25][CH:26]=1)[C:13]([C:31](=[O:34])[CH2:32][CH3:33])=[C:12]2[C:35]1[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 69156329HCID 69156329, compound

Product 1

HCID 69157093HCID 69157093, compound

Procedure

The present compound was synthesized by a method similar to that in Example 515 and using acetic anhydride and 4-(6-bromo-1-oxo-4-phenyl-3-propionyl-1H-isoquinolin-2-ylmethyl)benzenesulfonamide. 1H NMR (CDCl3) δ: 0.49 (3H, t, J=7.2 Hz), 1.71 (2H, q, J=7.2 Hz), 2.00 (3H, s), 5.36 (2H, s), 7.23-7.30 (2H, m), 7.39 (2H, d, J=8.4 Hz), 7.43-7.52 (4H, m), 7.68 (1H, dd, J=2.1, 8.7 Hz), 7.96 (2H, d, J=8.4 Hz), 8.38 (1H, d, J=8.7 Hz). HPLC analysis: purity 99.4% (retention time: 4.50 min). MS (ESI+): 567 (M+H), 569.

Workup

  1. customThe present compound was synthesized by a method similar to that in Example 515

Sources & evidence

ORD record
ord-4467bc6b62a845be9ca94b4b9852877e
Source dataset
uspto-grants-2008_07
Patent number
US07402595B2

Reaction notes

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