反应详情

To a 100 mL round-bottom flask fitted with a 3-way valve and a hydrogen-filled balloon, were added (S)-tert-butyl (1-(6-(3,6-dihydro-2H-pyran-4-yl)-1-methyl-1H-pyrrolo[3,2-b]pyridin-5-yl)ethyl)carbamate (1.23 g, 3.44 mmol) in MeOH (20 mL) along with palladium hydroxide on carbon (0.097 g, 0.688 mmol). The flask was evacuated and hydrogen introduced via the three-way valve. The reaction mixture was stirred overnight at RT. The next day an additional equivalence of Pd(OH)2 was added and the reaction mixture was stirred overnight. The reaction mixture was subsequently diluted with EtOAc, filtered through a pad of Celite, and concentrated to give the title compound as a yellow oil, which was used without further purification.

1. customTo a 100 mL round-bottom flask fitted with a 3-way valve
2. customThe flask was evacuated
3. additionhydrogen introduced via the three-way valve
4. additionThe next day an additional equivalence of Pd(OH)2 was added
5. stirringthe reaction mixture was stirred overnight
6. additionThe reaction mixture was subsequently diluted with EtOAc
7. filtrationfiltered through a pad of Celite
8. concentrationconcentrated