反应详情

温度

25 °C

To a 3-necked flask equipped with mechanical stirrer, thermometer and nitrogen inlet was added 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one free base (5.0 g) and 1-methyl-2-pyrrolidinone (60 mL) under nitrogen and the suspension was warmed up to 35–40° C. to dissolution. The flask was cooled to about 25° C. A 20.5% anhydrous solution of hydrogen chloride in isopropanol (6.45 g) was added and the mixture was stirred at about 25° C. for about 3 h. The product was collected by filtration on a Buchner funnel. The filter cake is rinsed twice with 10 mL of isopropanol at 20–25° C. and the damp cake transferred to a flask equipped with magnetic stirrer and nitrogen inlet. Isopropanol was added (30 mL) and the suspension stirred at 20–25° C. for about 2 h. The product was collected by filtration on a Buchner funnel. The filter cake is rinsed with 3×10 mL of isopropanol at 20–25° C. and transferred to a drying oven and dried in vacuo at 70–75° C. for 43 h. This afforded 4.52 g of anhydrous ziprasidone hydrochloride. The material contained 3.1% and 0.26% of residual NMP and IPA, respectively as determined by NMR.

1. customTo a 3-necked flask equipped with mechanical stirrer
2. temperaturethe suspension was warmed up to 35–40° C. to dissolution
3. filtrationThe product was collected by filtration on a Buchner funnel
4. washThe filter cake is rinsed twice with 10 mL of isopropanol at 20–25° C.
5. customthe damp cake transferred to a flask
6. customequipped with magnetic stirrer and nitrogen inlet
7. additionIsopropanol was added (30 mL)
8. stirringthe suspension stirred at 20–25° C. for about 2 h
9. filtrationThe product was collected by filtration on a Buchner funnel
10. washThe filter cake is rinsed with 3×10 mL of isopropanol at 20–25° C.
11. customtransferred to a drying oven
12. customdried in vacuo at 70–75° C. for 43 h