反应详情

温度

22 °C

A solution of [(3R,4S)-1-allyl-4-amino-4-(3-bromophenyl)pyrrolidin-3-yl]methanol (27 g; 86.7 mmol) in tetrahydrofuran (270 mL) is cooled to −5° C. under a nitrogen atmosphere. Benzoyl isothiocyanate (12.3 mL, 91 mmol) is added drop wise keeping the temperature below 0° C. The reaction is allowed to warm to 22° C. over 1 hour. 1,1′-Carbonyldiimidazole (28.1 g, 173.5 mmol) is added in a single portion and the reaction is stirred for 1 hour at 22° C. and then heated to reflux for 16 hours. The solvent is removed in vacuo and the residue dried under vacuum. The crude material is partitioned in methyl tert-butyl ether (500 mL) and water (250 mL). The organic layer is separated, dried over magnesium sulfate, filtered and evaporated to dryness. The crude material is purified over a silica gel gradient of 90/10 to 60/40 methylene chloride/ethyl acetate to give the title compound (27 g, 68%). ES/MS (m/e): 456 (M+1).

1. customthe temperature below 0° C
2. temperatureheated
3. temperatureto reflux for 16 hours
4. customThe solvent is removed in vacuo
5. customthe residue dried under vacuum
6. customThe crude material is partitioned in methyl tert-butyl ether (500 mL)
7. customThe organic layer is separated
8. dry with materialdried over magnesium sulfate
9. filtrationfiltered
10. customevaporated to dryness
11. customThe crude material is purified over a silica gel gradient of 90/10 to 60/40 methylene chloride/ethyl acetate