反应详情

To 3-(3-ethyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-ylcarbamoyl) imidazo[1,2-a]pyridine-7-carboxylic acid (26 mg, 0.057 mmol; prepared as in Example 28, step A) in DMF (2 mL) was added di(1H-imidazol-1-yl)methanone (14 mg, 0.086 mmol). The reaction mixture was stirred at ambient temperature for 1 hour. Dimethylamine (286 μL, 0.57 mmol) was added to the reaction mixture. The reaction vial was sealed and the mixture was heated at 70° C. for 2 hours. The mixture was cooled to ambient temperature. The DMF was removed under reduced pressure. The residue was purified by silica gel chromatography (DCM/MeOH 10:1) to provide the final product (10 mg). MS (ES+APCI) m/z=482 (M+H).

1. customThe reaction vial was sealed
2. temperaturethe mixture was heated at 70° C. for 2 hours
3. temperatureThe mixture was cooled to ambient temperature
4. customThe DMF was removed under reduced pressure
5. customThe residue was purified by silica gel chromatography (DCM/MeOH 10:1)