反应详情

N-(4-(4-Benzylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)nicotinamide (0.080 g, 0.19 mmol) was placed in MeOH (2 mL). Pd/C (0.0206 g, 0.0194 mmol) was then added, followed by the addition of 4 drops of concentrated HCl. The reaction was then placed under a balloon of H2 and stirred overnight. The reaction was filtered, washed with MeOH and concentrated to give the crude product N-(4-(piperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)nicotinamide (0.050 g, 79.9% yield) which was used without further purification.

1. filtrationThe reaction was filtered
2. washwashed with MeOH
3. concentrationconcentrated