反应详情

7-(3,5-Dimethylisoxazol-4-yl)-6-methoxy-N4-((tetrahydro-2H-pyran-4-yl)methyl)quinoline-3,4-diamine (for a preparation see Intermediate 17) (32 mg, 0.084 mmol) was dissolved in ethanol (3 ml) and cyanogen bromide (8.86 mg, 0.084 mmol) was added, then the mixture stirred overnight at room temperature. The reaction mixture was evaporated to dryness, the residue dissolved in DMSO (1 ml) and purified by MDAP (formate) to give 7-(3,5-dimethylisoxazol-4-yl)-8-methoxy-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-imidazo[4,5-c]quinolin-2-amine (4.5 mg, 0.011 mmol, 13.2% yield) as a yellow glass. LCMS (formate) Rt 0.65 min, MH+ 408

1. customThe reaction mixture was evaporated to dryness
2. dissolutionthe residue dissolved in DMSO (1 ml)
3. custompurified by MDAP (formate)