反应详情

温度

60 °C

Part F: Preparation of methyl 2-[[4-[4-(trifluoromethyl)phenoxy]-1-piperidinyl]-sulfonyl]butanoate. To a solution of the methylene sulfonamide from Part E (6.15 g, 16 mmol) in dimethylformamide (32 mL) were added potassium carbonate (7.8 g, 56.6 mmol), bis-(2-bromoethyl)amine ethyl carbamate (3.0 g, 10.75 mmol; partially purified) and 18-Crown-6 (500 mg). The resulting slurry was stirred at 60° C. After sixteen hr, potassium carbonate (2.0 g, 14 mmol) was added and the reaction stirred at 60° C. After a total of twenty four hr, the reaction was concentrated in vacuo. The residue was taken up in ethyl acetate, washed with water three times, brine, dried over Na2SO4, filtered, and concentrated in vacuo. Chromatography (on silica, ethyl acetate/hexanes) provided the ethyl sulfonamide as a light yellow oil (0.3 g, 10%).

1. custompartially purified) and 18-Crown-6 (500 mg)
2. waitAfter sixteen hr
3. stirringthe reaction stirred at 60° C
4. concentrationAfter a total of twenty four hr, the reaction was concentrated in vacuo
5. washwashed with water three times, brine
6. dry with materialdried over Na2SO4
7. filtrationfiltered
8. concentrationconcentrated in vacuo