反应详情

The title compound (300 mg, 83%) was prepared from (2R)-2-methyl-2-(methylsulfonyl)-4-[2-oxo-4-(4-{[trans-4-(tetrahydro-2H-pyran-2-yloxy)cyclohexyl]methoxy}phenyl)pyridin-1(2H)-yl]-N-(tetrahydro-2H-pyran-2-yloxy)butanamide (480 mg, 0.726 mmol) by a procedure analogous to that described for (2R)-N-hydroxy-4-[4-{4-[(cis-4-hydroxycyclohexyl)methoxy]phenyl}-2-oxopyridin-1(2H)-yl]-2-methyl-2-(methylsulfonyl)butanamide Example 8, Step F. LCMS m/z 493.7 (M+1)H NMR (400 MHz, DMSO-d6) δ ppm 0.92-1.23 (m, 4 H) 1.54 (s, 3 H) 1.58-1.72 (m, 1 H) 1.81 (br. s., 4 H) 2.06-2.21 (m, 1 H) 2.41 (s, 1 H) 3.08 (s, 3 H) 3.25-3.41 (m, 1 H) 3.74 (br. s., 1 H) 3.80 (d, J=6.44 Hz, 2 H) 3.98-4.17 (m, 1 H) 6.48-6.71 (m, 2 H) 6.85-7.06 (m, 2 H) 7.52-7.78 (m, 3 H) 11.15 (s, 1 H)