Hydrochloric Acid → beta-Amino-alanine ethyl ester hydrochloride

HRID 843725Notes

Reaction equation

HRID 843725 reaction equation
[CH2:1]([O:3][C:4](=[O:34])[C@@H:5]([NH:26]C(OC(C)(C)C)=O)[CH2:6][NH:7]C([C@@H]1CCCN(C(OCC2C=CC=CC=2)=O)C1)=O)[CH3:2].[ClH:35]>C(OCC)(=O)C>[ClH:35].[CH2:1]([O:3][C:4](=[O:34])[C@@H:5]([NH2:26])[CH2:6][NH2:7])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86584062N-[(R)-(1-benzyloxycarbonyl-3-piperidyl)carbonyl]-2(S)-(tert-butoxycarbonylamino)-beta-alanine ethyl ester

Product 1

HCID 86584061beta-Amino-alanine ethyl ester hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Conditions

Temperature
0 °C

Procedure

To a solution of N-[(R)-(1-benzyloxycarbonyl-3-piperidyl)carbonyl]-2(S)-(tert-butoxycarbonylamino)-β-alanine ethyl ester (0.4 g) in ethyl acetate (4 ml) was added 4N HCl in ethyl acetate (2.1 ml) under stirring at 0° C. After stirring at ambient temperature for 2 hours, the resulting precipitates were collected by filtration to give N-[(R)-1-benzyloxycarbonyl-3-piperidyl)carbonyl]-2(S)-amino-β-alanine ethyl ester hydrochloride (0.31 g).

Workup

  1. stirringAfter stirring at ambient temperature for 2 hours
  2. customthe resulting precipitates
  3. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-d430fd47f484461fa1327cfc8018093e
Source dataset
uspto-grants-2002_04
Patent number
US06380215B1

Reaction notes

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