反应详情

To a mixture of 1-(4-nitrobenzoyl)-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydrocarbostyril (1.5 g) and ethanol (30 ml) were added DMF (5 ml) and 10% palladium on carbon (300 mg). The mixture was hydrogenated at 50° to 60° C. After competion of reaction, the catalyst was filtered off and the filtrate was evaporated under reduced pressure. The resultant residue was purified by silica-gel column chromatography (eluent:dichloromethane:methanol= 100:2) and recrystallized from ethanol to give 1-(4-aminobenzoyl)-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydrocarbostyril (0.45 g).

1. customwas hydrogenated at 50° to 60° C
2. customAfter competion of reaction
3. filtrationthe catalyst was filtered off
4. customthe filtrate was evaporated under reduced pressure
5. customThe resultant residue was purified by silica-gel column chromatography (eluent:dichloromethane:methanol= 100:2)
6. customrecrystallized from ethanol