反应详情

1-(3-Benzyloxybenzoyl)-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydrocarbostyril (6 g) was dissolved in a mixture of ethanol (100 ml) and DMF (50 ml), and 10% palladium on carbon (1 g) was added thereto. The mixture was hydrogenated at 50° C. After completion of reaction, the catalyst was filtered off and the filtrate was evaporated under reduced pressure. The resultant residue was purified by silica-gel column chromatography (eluent:ethyl acetate:methanol=100:2) to give 1-(3-hydroxybenzoyl)-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydrocarbostyril (4.0 g).

1. additionwas added
2. customwas hydrogenated at 50° C
3. customAfter completion of reaction
4. filtrationthe catalyst was filtered off
5. customthe filtrate was evaporated under reduced pressure
6. customThe resultant residue was purified by silica-gel column chromatography (eluent:ethyl acetate:methanol=100:2)