反应详情

温度

0 °C

Next, 2.02 g (11.4 mmol) of the above (+)-2-methyloctanoic acid chloride and 3 ml of nitrobenzene were charged into a flask, and cooled to 0° C., to which was added 3.06 g (22.9 mmol) of anhydrous aluminum chloride with stirring and then the resulting mixture was stirred at room temperature for 30 minutes. This mixture was added with a solution of 2.89 g (7 mmol) of (+)-2-methyloctanoic acid biphenyl dissolved in 3 ml of nitrobenzene, which was reacted at room temperature for 140 hours with stirring. After the completion of the reaction, 2N hydrochloric acid and ice were added, and the extraction with chloroform was carried out, and the extract was washed with water, dried on anhydrous magnesium sulfate, distilled to remove the solvent, and purified by a column chromatography of silica gel to obtain 1.55 g (yield 49%) of an oily (+)-2-methyloctanoic acid-4-(2-methyloctanoyl) biphenyl.

1. stirringthe resulting mixture was stirred at room temperature for 30 minutes
2. customwhich was reacted at room temperature for 140 hours
3. stirringwith stirring
4. additionwere added
5. extractionthe extraction with chloroform
6. washthe extract was washed with water
7. dry with materialdried on anhydrous magnesium sulfate
8. distillationdistilled
9. customto remove the solvent
10. custompurified by a column chromatography of silica gel