反应详情

To 7-hexyloxy-2-methyl-2-phenylthiazolo[3,2-a]indol-3(2H)-one (3.92 g), 2N sodium hydroxide (70 ml) was added, and the mixture was heated and refluxed for 1.5 hours. The reaction mixture was allowed to cool, and the deposited crystalline matter was collected by filtration. The crystalline matter was dissolved in methanol. The solution was made acidic by adding concentrated hydrochloric acid under ice cooling, and the solvent was evaporated under reduced pressure. Water was added to the residue, and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, to give 3.81 g (yield: 93 %) of the desired compound as a colorless powder. The melting point was 100°-102° C.

1. temperaturethe mixture was heated
2. temperaturerefluxed for 1.5 hours
3. temperatureto cool
4. filtrationthe deposited crystalline matter was collected by filtration
5. dissolutionThe crystalline matter was dissolved in methanol
6. additionby adding concentrated hydrochloric acid under ice cooling
7. customthe solvent was evaporated under reduced pressure
8. additionWater was added to the residue
9. extractionthe mixture was extracted with ethyl acetate
10. dry with materialThe organic layer was dried over anhydrous sodium sulfate
11. customThe solvent was evaporated under reduced pressure