反应详情

LAH (1.04 g, 0.0273 mol, 3.0 eq) was dissolved in THF (25 ml), and to this solution was added dropwise a THF solution (25 ml) of (2-benzyloxyphenyl)-acetonitrile (2.04 g, 0.0091 mol, 1.0 eq) under ice-cooling. After the completion of the dropwise addition, the mixture was stirred at room temperature for 15 minutes and refluxed under heating for 2 hours. This reaction mixture was cooled with ice-cold water, and a saturated aqueous sodium sulfate solution (about 30-40 ml) was added. After filtration through Celite, the filtrate was concentrated under reduced pressure. The obtained residue was purified by column chromatography (chloroforn/methanol=5/1) to give 2-(2-benzyloxyphenyl)ethylamine (0.415 g, 20.0%) as a pale-yellow amorphous compound.

1. temperaturecooling
2. additionAfter the completion of the dropwise addition
3. temperaturerefluxed
4. temperatureunder heating for 2 hours
5. temperatureThis reaction mixture was cooled with ice-cold water
6. filtrationAfter filtration through Celite
7. concentrationthe filtrate was concentrated under reduced pressure
8. customThe obtained residue was purified by column chromatography (chloroforn/methanol=5/1)