反应详情

[1-(2,4-Dimethoxy-benzyl)-4,4-dimethyl-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl]-carbamic acid tert-butyl ester (260 mg, 0.64 mmol) was dissolved in methanol (10 ml). Palladium on charcoal (30 mg, 10%) was added and the mixture was hydrogenated at room temperature for 90 minutes. The catalyst was filtered off and the filtrate was evaporated. The residue was purified by flash chromatography (heptane/ethyl acetate=1:1) to yield 220 mg (84%) of [1-(2,4-dimethoxy-benzyl)-4,4-dimethyl-2-oxo-azepan-3-yl]-carbamic acid tert-butyl ester as a colourless oil; MS: m/e=407.4 (MH+).

1. filtrationThe catalyst was filtered off
2. customthe filtrate was evaporated
3. customThe residue was purified by flash chromatography (heptane/ethyl acetate=1:1)