反应详情

A solution of 4.7 g of 2-(4-benzyloxy-phenoxy)-N-methyl-acetamide [Example 2c)] in 150 ml of tetrahydrofurane was hydrogenated at atmospheric pressure and room temperature using 470 mg of palladium on charcoal (10%) as the catalyst. For the working-up, the reaction mixture was filtered over a Dicalite layer and the resulting solution was evaporated under reduced pressure. The residue was triturated in ether and the solid collected on a filter funnel. After drying there were obtained 2.95 g (93% of theory) of 2-(4-hydroxy-phenoxy)-N-methyl-acetamide as white crystals; MS: m/e=181 (M)+.

1. customwas hydrogenated at atmospheric pressure and room temperature
2. filtrationthe reaction mixture was filtered over a Dicalite layer
3. customthe resulting solution was evaporated under reduced pressure
4. customThe residue was triturated in ether
5. customthe solid collected on a filter funnel
6. customAfter drying there