反应详情

To cold concentrated H2SO4 (3 mL) was added 8′-bromo-4′-methyl-3′,4′-dihydro-2′H-spiro[1,3-dioxane-2,10′-pyrimido[1,2-a]indole] (0.252 g, 0.747 mmol) in four portions with cooling in an ice bath. The reaction was then allowed to stir at room temperature for 1 hr. The mixture was poured onto ice and basified with NH4OH to pH 11 with cooling in an external ice bath. The reaction mixture was extracted with Et2O (2×). The combined organic extracts were dried over Na2SO4, filtered, and concentrated. The crude product was purified on Biotage KP silica gel eluting with CH2Cl2/CH3OH/NH4OH (96/2/1) to give the title compound as a red solid (0.138 g, 66% ). Anal. Calc'd for C12H11BrN2O: C, 51.64; H, 3.97; N, 10.04; Found: C, 51.23; H, 3.89; N, 9.88. NMR (300 Mz, DMSO-d6): consistent. MS: (ES+) m/z 278/280 [M+H]; 1 Br pattern observed. m.p.: 127-129° C.

1. temperaturewith cooling in an ice bath
2. additionThe mixture was poured onto ice
3. temperaturewith cooling in an external ice bath
4. extractionThe reaction mixture was extracted with Et2O (2×)
5. dry with materialThe combined organic extracts were dried over Na2SO4
6. filtrationfiltered
7. concentrationconcentrated
8. customThe crude product was purified on Biotage KP silica gel eluting with CH2Cl2/CH3OH/NH4OH (96/2/1)