反应详情

(8E,12E,14E)-7-acetoxy-6,10,12,16,20-pentamethyl-3,16,21-tris(triethylsiloxy)-18,19-epoxytricosa-8,12,14-trien-11-olide (77 mg, 0.0875 mmol) was dissolved in methanol (2 mL). Potassium carbonate (36.5 mg, 0.262 mmol) and methanol (1 mL) were added to this methanolic solution, and the reaction mixture was stirred at room temperature for four hours. The reaction mixture was diluted with ethyl acetate, and then the organic layer was washed with brine. The organic layer was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (Kanto silica gel 60N, 40 to 50 μm; ethyl acetate-hexane, 1:9->1:6->1:4->1:3) to obtain the title compound (38.6 mg, 50%) as a colorless oil.

1. washthe organic layer was washed with brine
2. dry with materialThe organic layer was dried with anhydrous magnesium sulfate
3. filtrationfiltered
4. concentrationconcentrated under reduced pressure
5. customThe resulting residue was purified by silica gel column chromatography (Kanto silica gel 60N, 40 to 50 μm; ethyl acetate-hexane, 1:9->1:6->1:4->1:3)