Hydrochloric Acid → 4-Fluoro-2-hydroxy-3-methylbenzaldehyde

To 2.19 g (17.36 mmol) of 3-fluoro-2-methylphenol in 87 mL of anhydrous acetonitrile was added 12.1 g (126.73 mmol) of MgCI2 portionwise followed by addition of 9.0 mL (64.93 mmol) of TEA to afford a pinkish reaction mixture. To this mixture was added 3.8 g (126.73 mmol) of paraformaldehyde and the resulting yellow colored mixture was heated to relux for 4 hours. After cooling to room temperature, to the mixture was added 5% HCl slowly. The reaction was extracted with EtOAc (3×), washed with satd NaCl (3×), dried over MgSO4, filtered, and concd to afford an oil, which was purified by silica gel chromatography with EtOAc/hexane (1:9) to afford 2.02 g (75%) of a pale tan oil which later solidified: 1H NMR (CDCl3/400 MHz) 2.14 (d, 3H, J=1.6 Hz), 6.68 (t, 1 H, J=8.8 Hz), 7.37 (dd, 1H, J=6.4, 8.4 Hz), 9.78 (s, 1H), 11.59 (d, 1H, J=2.0 Hz); HRMS (EI+) m/z calcd for (C8H7FO2) 154.0430, found 154.0428.

1. customto afford a pinkish reaction mixture
2. temperaturethe resulting yellow colored mixture was heated
3. extractionThe reaction was extracted with EtOAc (3×)
4. washwashed with satd NaCl (3×)
5. dry with materialdried over MgSO4
6. filtrationfiltered
7. customconcd to afford an oil, which
8. customwas purified by silica gel chromatography with EtOAc/hexane (1:9)

ORD record

ord-608ca2e9a0a44be3a1ebef7aa5708d68

Source dataset

uspto-grants-2007_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07259266B2