反应详情

温度

0 °C

4.37 g of 3-chloro-4-fluoro-phenylacetonitrile (25 mmol) were dissolved in 40 ml THF and cooled down to 0° C. under nitrogen. 132 ml of a 1M borane-THF complex solution in THF were then added dropwise over 30 min keeping the temperature between 0-5° C. After addition the reaction mixture was stirred at rt for additional 20 min, and refluxed for 21 h. The reaction mixture was then cooled down to 0° C. and treated between 2 and 5° C. with 30 ml methanol over a period of 45 min. After 1 h refluxing the reaction mixture was concentrated, the residue dissolved in DCM and the amine extracted twice with 1N aqueous HCl. The combined aqueous phases were then treated with concentrated NaOH to adjust the pH to 12, and then extracted twice with DCM. The combined organic phases were then washed with water, dried over magnesium sulfate, filtered and concentrated in vacuo leading to 4.3 g colorless oil. This was dissolved in 125 ml diethylether, treated with 15 ml 2.6N HCl in diethylether, stirred at rt for additional 1 h, filtered and dried under high vacuo, leading to 3.93 g white solid (75%). MS (ISP) 174.1 (M+H)+.

1. custombetween 0-5° C
2. additionAfter addition the reaction mixture
3. temperaturerefluxed for 21 h
4. temperatureThe reaction mixture was then cooled down to 0° C.
5. temperatureAfter 1 h refluxing the reaction mixture
6. concentrationwas concentrated
7. dissolutionthe residue dissolved in DCM
8. extractionthe amine extracted twice with 1N aqueous HCl
9. additionThe combined aqueous phases were then treated with concentrated NaOH
10. extractionextracted twice with DCM
11. washThe combined organic phases were then washed with water
12. dry with materialdried over magnesium sulfate
13. filtrationfiltered
14. concentrationconcentrated in vacuo
15. dissolutionThis was dissolved in 125 ml diethylether
16. additiontreated with 15 ml 2.6N HCl in diethylether
17. stirringstirred at rt for additional 1 h
18. filtrationfiltered
19. customdried under high vacuo