反应详情

The title compound was synthesized in analogy to 4-cyclopropyl benzaldehyde (described in example S53) using 1-bromo-4-(1-ethylcyclopropyl)-benzene (208 mg, 0.92 mmol), n-BuLi (635 μl, 1.6M solution in hexane, 1.02 mmol) and DMF (144 μl, 1.85 mmol). The isolated residue was purified by flash column chromatography (1:9 ether:pentane) to give 4-(1-ethylcyclopropyl)-benzaldehyde (130 mg, 81%) as a colorless oil. 1H NMR (CDCl3, 300 MHz): δ 9.97 (s, 1H), 7.80 (d, J=8.5 Hz, 2H), 7.43 (d, J=8.5 Hz, 2H), 1.65 (q, J=7.5 Hz, 2H), 0.86 (t, J=7.5 Hz, 3H), 0.89-0.82 (m, 2H), 0.79-0.75 (m, 2H).

1. customThe isolated residue was purified by flash column chromatography (1:9 ether:pentane)