反应详情

First, 50 g of 1-[4-chloro-6-fluoro-3-hydroxy-2-(2-methyl-2-propenyl)phenyl]-3-methyl-4-trifluoromethyl-1,2,3,6-tetrahydropyrimidine-2,6-dione was dissolved in 500 ml of chloroform, to which 30.0 g of m-chloroperbenzoic acid was added, and the reaction was allowed to proceed at 60° C. for 4.5 hours. After completion of the reaction, the reaction mixture was cooled to room temperature and subjected to phase separation with chloroform and aqueous sodium sulfite solution. The organic layer was successively washed with saturated aqueous sodium bicarbonate solution and water, dried and concentrated. The residue was recrystallized to afford 46 g of 1-[4-chloro-6-fluoro-3-hydroxy-2-(2,3-epoxy-2-methylpropyl)phenyl]-3-methyl-4-trifluoromethyl-1,2,3,6-tetrahydropyrimidine-2,6-dione.

1. additionwas added
2. customAfter completion of the reaction
3. customsubjected to phase separation with chloroform and aqueous sodium sulfite solution
4. washThe organic layer was successively washed with saturated aqueous sodium bicarbonate solution and water
5. customdried
6. concentrationconcentrated
7. customThe residue was recrystallized