反应详情

To a mixture of 0.933 g(3 mmol) of 4-(8-chloro-5,6-dihydro-11H-benzo-[5,6]cyclohepta(1,2-b]pyridin-11-ylidene)-piperidine (product from Preparative Example 1, step G), 0.46 g(3 mmol) of 4-pyridyl acetic acid N-oxide (prepared as described in Preparative Example 8) 1-hydroxybenzotriazole (0.40 g, 3 mmol) in 20 mL of DMF at ~4° C. and under nitrogen atmosphere was added N- methyl morpholine(1.65 mL, 15 mmol) followed by DEC an reaction stirred overnight at room temperature. The volatiles were stripped off and the resulting semi-solid was partitioned between water and EtOAc. The aqueous phase was washed twice with EtOAc. Combined EtOAc fractions were dried over Na2SO4 and concentrated. The crude product was purified via flash chromatography on silica gel (first eluting with 3% and then 5% MeOH saturated with ammonia in CH2Cl2) to give the title compound as a light brown solid(0.2 g mp=128°-130° C. MH+ 446).

1. customthe resulting semi-solid was partitioned between water and EtOAc
2. washThe aqueous phase was washed twice with EtOAc
3. dry with materialCombined EtOAc fractions were dried over Na2SO4
4. concentrationconcentrated
5. customThe crude product was purified via flash chromatography on silica gel (
6. washfirst eluting with 3%