反应详情

To a 10 mL round bottom flask was added N-(4-(6-(2-(4-fluorophenyl)-2-methylpropylamino)pyridazin-3-yl)-1H-imidazol-2-yl)acetamide (22 mg, 59 μmol), concentrated HCl (100 μL) and methanol (1 mL). The reaction was refluxed for 12 h and then concentrated, redissolved in EtOAc (10 mL), washed with saturated sodium carbonate (2×10 mL) and brine (1×10 mL), dried (Na2SO4) and concentrated to yield 8 mg (42%) of 6-(2-amino-1H-imidazol-4-yl)-N-(2-(4-fluorophenyl)-2-methylpropyl)pyridazin-3-amine as a pale yellow solid, m/z=327.2 [M+H].

1. temperatureThe reaction was refluxed for 12 h
2. concentrationconcentrated
3. dissolutionredissolved in EtOAc (10 mL)
4. washwashed with saturated sodium carbonate (2×10 mL) and brine (1×10 mL)
5. dry with materialdried (Na2SO4)
6. concentrationconcentrated