反应详情

A mixture of tert-butyl 4-(4-{[(benzyloxy)carbonyl]amino}-2-methoxyphenyl)piperidine-1-carboxylate (Preparation Example 454) (4.92 g), trifluoroacetic acid (10 mL) and 1,2-dichloroethane (50 mL) was stirred at room temperature for 1 hour. The reaction solvent was concentrated under reduced pressure, and after addition of saturated aqueous sodium hydrogen carbonate, the residue was extracted with chloroform. After drying over anhydrous magnesium sulfate, the solvent was distilled off, and the residue was solidified by addition of diethyl ether to give benzyl (3-methoxy-4-piperidin-4-ylphenyl)carbamate (3.24 g) as a white solid.

1. concentrationThe reaction solvent was concentrated under reduced pressure
2. additionafter addition of saturated aqueous sodium hydrogen carbonate
3. extractionthe residue was extracted with chloroform
4. dry with materialAfter drying over anhydrous magnesium sulfate
5. distillationthe solvent was distilled off
6. additionthe residue was solidified by addition of diethyl ether