反应详情

tert-Butyl 2-((2-aminoethyl)(methyl)amino)ethylcarbamate (500 mg, 2.3 mmol) was taken up in 10 mL of CH3CN along with salicylic acid (310 mg, 2.3 mmol) and EDCI (485 mg, 2.53 mmol). The resulting reaction mixture was stirred at room temperature for 18 h and then diluted with EtOAc. The organic layer was washed with saturated aqueous NaHCO3, brine, dried (Na2SO4) and concentrated under reduced pressure. The resulting residue was purified by chromatography (95% CH2Cl2, 5% MeOH) to afford 380 mg of tert-butyl 2-((2-(2-hydroxybenzamido)ethyl)(methyl)amino)ethylcarbamate (49% yield). MS (EI) calcd for C17H27N3O4: 337.2. found: 338 (M+1).

1. customThe resulting reaction mixture
2. washThe organic layer was washed with saturated aqueous NaHCO3, brine
3. dry with materialdried (Na2SO4)
4. concentrationconcentrated under reduced pressure
5. customThe resulting residue was purified by chromatography (95% CH2Cl2, 5% MeOH)