反应详情

Prepared as in example 5.6.3 from 1-[5-(6-fluoro-imidazo[1,2-b]pyridazine-3-yl)-thiophen-2-yl]-ethanone (50 mg, 0.2 mmol) and racemic 2-methylbutylamine [96-15-1] (42 mg, 0.5 mmol). Purification by preparative RP-HPLC provided 1-{5-[6-(2-methyl-butylamino)-imidazo[1,2-b]pyridazin-3-yl]-thiophen-2-yl}-ethanone as a yellow solid. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 0.88-1.01 (m, 5H) 1.19-1.30 (m, 1H) 1.50-1.61 (m, 4H) 1.89 (dq, J=13.29, 6.74 Hz, 1H) 2.54 (s, 2H) 3.26-3.33 (m, 1H) 3.40-3.49 (m, 1H) 4.57 (t, J=5.73 Hz, 1H) 6.43-6.47 (m, 1H) 7.21 (s, 1H) 7.56-7.58 (m, 1H) 7.61-7.67 (m, 2H) 7.90 (s, 1H). LRMS (ESI) m/z 329.1 [(M+H)]+, calc'd for C17H20N40S: 328.44.

1. customPurification by preparative RP-HPLC